This talk shows how religious belief is incompatible with, and undermines, every aspect of a healthy thinking process. In its metaphysics, religion advocates the primacy of consciousness and upholds an invalid view of free will. In its epistemology, it makes knowledge, including proper concept-formation, impossible. In its ethics, it negates all the virtues that make human life possible, including rationality, independence, justice, and pride. And psycho-epistemologically, religion encourages passivity, evasion, and non-integration. In addition to demonstrating the harmful effects of religion, Dr. Locke addresses the question of why many religionists appear to be happy and to live successful lives.