On January 16, 2018, Brook argued the affirmative in a debate with Epstein over whether selfishness is a virtue. It was an Oxford-style contest, in which the audience votes on the proposition before and after the event, and the side that sways the most people wins. Epstein was victorious, picking up 15.38 percent of the undecideds vs. 9.89 percent for Yaron Brook. Judge Andrew Napolitano, senior judicial analyst at Fox News Channel, moderated.

The event was held by The Soho Forum, Reason Foundation's debate series in New York City. Held every month at the SubCulture Theater in the East Village, it also serves as a gathering place for New York's libertarian community, with free food and a cash bar. Epstein is also the Soho Forum's director and usually moderates.